Article

CDK5/CAMK2-DRP1-AMPK-Mediated Mitochondrial Fission is Required for Imatinib Resistance of CML Cells

2020-08-06

Abstract excerpt

<h4>Background: </h4> In chronic myeloid leukemia (CML), resistance to tyrosine kinase inhibitors (TKIs) is still a serious clinical challenge, especially in the context of multi-resistance BCR-ABL mutations, such as T315I. Increasing evidence has demonstrated that mitochondrial fission plays an important role in cancer stem cell maintenance and drug resistance. Therefore, as a vital fission-related protein, DRP1...

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Literature Corpus work: 669c47b9-6eb2-57a2-900c-60a78a72509b
DOI: 10.21203/rs.3.rs-52123/v1

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