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Transcriptome analysis reveals PRKCA as a potential therapeutic target for overcoming cisplatin resistance in lung cancer through ferroptosis

1 May 2024

Abstract excerpt

Cisplatin-based chemotherapy is the current standard care for lung cancer patients; however, drug resistance frequently develops during treatment, thereby limiting therapeutic efficacy.The molecular mechanisms underlying cisplatin resistance remain elusive. In this study, we conducted an analysis of microarray data from the Gene Expression Omnibus (GEO) database under the accession numbers GSE21656,which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38765024
DOI: 10.1016/j.heliyon.2024.e30780

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