Article

Simulating the human tumor microenvironment in colorectal cancer organoids <i>in vitro</i> and <i>in vivo</i>

2019-11-01

Abstract excerpt

The tumor microenvironment (TME) plays a significant role in cancer growth and metastasis. Bioengineered models of the TME will advance our understanding of cancer progression and facilitate identification of novel anti-cancer therapeutics that target TME components such as extracellular matrix (ECM) and stromal cells. However, most current in vitro models fail to recapitulate the extensive features of the human...

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Literature Corpus work: dca9c4d9-2455-5b32-a83f-c20f4428d6df
DOI: 10.1101/822684

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