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Article

Simulating the human colorectal cancer microenvironment in 3D tumor-stroma co-cultures in vitro and in vivo.

Scientific reports - 17 Jun 2020

Devarasetty Mahesh, Dominijanni Anthony, Herberg Samuel, Shelkey Ethan, Skardal Aleksander, Soker Shay

Abstract excerpt

The tumor microenvironment (TME) plays a significant role in cancer progression and thus modeling it will advance our understanding of cancer growth dynamics and response to therapies. Most in vitro models are not exposed to intact body physiology, and at the same time, fail to recapitulate the extensive features of the tumor stroma. Conversely, animal models do not accurately capture the human tumor...

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Identifiers

PMID: 32555362
DOI: 10.1038/s41598-020-66785-1
PMCID: PMC7300090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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