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Article

Bioengineered Submucosal Organoids for In Vitro Modeling of Colorectal Cancer.

Tissue engineering. Part A - 1 Oct 2017

Devarasetty Mahesh, Skardal Aleksander, Cowdrick Kyle, Marini Frank, Soker Shay

Abstract excerpt

The physical nature of the tumor microenvironment significantly impacts tumor growth, invasion, and response to drugs. Most in vitro tumor models are designed to study the effects of extracellular matrix (ECM) stiffness on tumor cells, while not addressing the effects of ECM's specific topography. In this study, we bioengineered submucosal organoids, using primary smooth muscle cells embedded in collagen I...

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Identifiers

PMID: 28922975
DOI: 10.1089/ten.tea.2017.0397
PMCID: PMC5653148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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