Article

T Cell Receptor Immunotherapy Drives Human Immunodeficiency Virus Evolution in Humanized Mice

2019-03-12

Abstract excerpt

<h4>Summary</h4> T cell receptor mediated immunotherapy using engineered Hematopoietic Stem/Progenitor Cells leads to durable partial suppression of HIV in humanized mice. Sustained viral suppression is accompanied by viral evolution under selection pressure. This study highlights the potential for TCR immunotherapy and the need to target multiple epitopes. Effective CD8+ T cell responses targeted to the KK10 epi...

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Literature Corpus work: dca87719-5e5b-50da-9334-9ee601ae2bab
DOI: 10.1101/574608

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