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Article

Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice.

PloS one - 7 Dec 2009

Kitchen Scott G, Bennett Michael, Galić Zoran, Kim Joanne, Xu Qing, Young Alan, Lieberman Alexis, Joseph Aviva, Goldstein Harris, Ng Hwee, Yang Otto, Zack Jerome A

Abstract excerpt

There is a desperate need for effective therapies to fight chronic viral infections. The immune response is normally fastidious at controlling the majority of viral infections and a therapeutic strategy aimed at reestablishing immune control represents a potentially powerful approach towards treating persistent viral infections. We examined the potential of genetically programming human hematopoietic stem cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19997617
DOI: 10.1371/journal.pone.0008208
PMCID: PMC2785433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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