Article

Pharmacological modulation of glutamatergic and neuroinflammatory pathways in a Lafora disease mouse model

2022-02-16

Abstract excerpt

<title>Abstract</title> <p>Lafora disease (LD) is a fatal rare neurodegenerative disorder that affects young adolescents and has no treatment yet. The hallmark of LD is the presence of polyglucosan inclusions (PGs), called Lafora bodies (LBs), in the brain and peripheral tissues. LD is caused by mutations in either <italic>EPM2A</italic> or <italic>EPM2B</italic> genes, which respectively encode laforin, a glucan...

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Literature Corpus work: 5c3a9332-ba7a-59a3-9910-aefa4a9ea4fd
DOI: 10.21203/rs.3.rs-1349685/v1

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