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How is Excitotoxicity Being Modelled in iPSC-Derived Neurons?

1 Oct 2024

Abstract excerpt

Excitotoxicity linked either to environmental causes (pesticide and cyanotoxin exposure), excitatory neurotransmitter imbalance, or to intrinsic neuronal hyperexcitability, is a pathological mechanism central to neurodegeneration in amyotrophic lateral sclerosis (ALS). Investigation of excitotoxic mechanisms using in vitro and in vivo animal models has been central to understanding ALS mechanisms of disease. In...

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PMID: 39405005
DOI: 10.1007/s12640-024-00721-3

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