Article
Genetics of Parkinson's disease: An introspection of its journey towards precision medicine.
Neurobiology of disease - 1 Apr 2020
Bandres-Ciga Sara, Diez-Fairen Monica, Kim Jonggeol Jeff, Singleton Andrew B
Abstract excerpt
A substantial proportion of risk for Parkinson's disease (PD) is driven by genetics. Progress in understanding the genetic basis of PD has been significant. So far, highly-penetrant rare genetic alterations in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1 and GBA have been linked with typical familial PD and common genetic variability at 90 loci have been linked to risk for PD. In this review, we outline the journey thus...
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