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NLP-12/Cholecystokinin signaling stabilizes sensory dendritic structure and protects neuronal healthspan in <i>Caenorhabditis elegans</i>

2026-03-09

Abstract excerpt

<h4>ABSTRACT</h4> Aging selectively degrades neuronal structure and function, yet the signals that actively preserve neuronal integrity over adult life remain incompletely defined. In Caenorhabditis elegans , the PVD sensory neuron develops progressive excessive higher-order dendritic branching during normal aging that correlates with declines in proprioceptive locomotion. Using this system as a quantitative in...

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Literature Corpus work
dc521f04-cdc9-5cd1-93f6-67ff230cbea2
DOI
10.64898/2026.03.05.709874
Open publication

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