Article
A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior.
PLoS genetics - 1 Aug 2014
Bhattacharya Raja, Touroutine Denis, Barbagallo Belinda, Climer Jason, Lambert Christopher M, Clark Christopher M, Alkema Mark J, Francis Michael M
Abstract excerpt
An organism's ability to thrive in changing environmental conditions requires the capacity for making flexible behavioral responses. Here we show that, in the nematode Caenorhabditis elegans, foraging responses to changes in food availability require nlp-12, a homolog of the mammalian neuropeptide cholecystokinin (CCK). nlp-12 expression is limited to a single interneuron (DVA) that is postsynaptic to...
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