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Article

The Wnt/β-Catenin Signaling Pathway as a Target in Drug Discovery

1 Jan 2007

Abstract excerpt

The cell signaling cascades provoked by Wnt proteins (the Wnt signaling pathways), which are well conserved through evolution, play crucial roles to maintain homeostasis of a variety of tissues such as skin, blood, intestine, and brain, as well as to regulate proliferation, morphology, motility, and fate of cells during embryonic development. Among these pathways, the signal transduction through beta-catenin (the...

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PMID: 17721040
DOI: 10.1254/jphs.cr0070024

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