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Wnt5a suppresses colorectal cancer progression via TGF-β/NOTUM/OLFM4 axis in patient-derived organoids

5 Aug 2025

Abstract excerpt

BACKGROUND: Wnt5a, a noncanonical Wnt ligand, exhibits dual roles in cancer progression, but its tumor-suppressive mechanisms in colorectal cancer (CRC) remain poorly defined. Stromal-derived signals in the tumor microenvironment (TME) are increasingly recognized as critical modulators of CRC behavior, yet their interplay with therapeutic resistance is unclear. METHODS: Using patient-derived CRC organoids (PDOs)...

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PMID: 40765051
DOI: 10.1186/s12964-025-02364-z

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