Article

Interferon Beta Drives Therapy Resistance in a Patient-Derived Model of High-Grade Serous Ovarian Cancer

2026-01-28

Abstract excerpt

<h4>ABSTRACT</h4> Cancer cell-autonomous type 1 interferon (IFN-1) production and signaling is frequently activated in response to DNA damage and has been associated with the development of therapy resistance in several cancer types. However, its cell-autonomous role in driving resistance in high-grade serous ovarian cancer (HGSOC), a disease defined by near-universal exposure to genotoxic therapy as frontline tr...

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Literature Corpus work: dc3a0c28-80bd-5924-8d5e-82b21ebe7d64
DOI: 10.64898/2026.01.27.699126

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