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DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer

27 Apr 2017

Abstract excerpt

High-grade serous ovarian cancer is the most common ovarian cancer type. Although the combination of surgery and platinum-taxane chemotherapy provide an effective treatment, drug resistance frequently occurs leading to poor outcome. In order to clarify the molecular mechanisms of drug resistance, the DNA methylation and transcriptomic changes, associated with the development of drug resistance in high-grade...

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PMID: 28473707
DOI: 10.1038/s41598-017-01624-4

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