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Article

Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells.

Scientific reports - 2 Aug 2017

Sonego Maura, Pellizzari Ilenia, Dall'Acqua Alessandra, Pivetta Eliana, Lorenzon Ilaria, Benevol Sara, Bomben Riccardo, Spessotto Paola, Sorio Roberto, Gattei Valter, Belletti Barbara, Schiappacassi Monica, Baldassarre Gustavo

Abstract excerpt

Standard of care for Epithelial Ovarian Cancer (EOC) patients relies on platinum-based therapy. However, acquired resistance to platinum occurs frequently and predicts poor prognosis. To understand the mechanisms underlying acquired platinum-resistance, we have generated and characterized three platinum-resistant isogenic EOC cell lines. Resistant cells showed 3-to 5- folds increase in platinum IC50....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28769043
DOI: 10.1038/s41598-017-07005-1
PMCID: PMC5540908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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