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Does neoadjuvant chemotherapy bias the transcriptomic profile of platinum-sensitive advanced high grade serous ovarian cancer patients towards a resistant phenotype? Findings from a gene expression meta-analysis

2025-09-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Chemoresistance is the key determinant of long-term survival in advanced high-grade serous ovarian cancer (HGSOC). The molecular mechanisms underlying chemoresistance in clinical populations are not clearly known. The study aimed to analyze the molecular mechanisms promoting chemoresistance, as well as neoadjuvant chemotherapy (NACT) induced sensitive-to-resistant transforma...

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Literature Corpus work
a9342141-310f-5867-a024-d2b60fcaa351
DOI
10.1101/2025.09.23.25336416
Open publication

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Does neoadjuvant chemotherapy bias the transcriptomic profile of platinum-sensitive advanced high grade serous ovarian cancer patients towards a resistant phenotype? Findings from a gene expression meta-analysisDOI 10.1101/2025.09.23.25336416
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