Article

Variant-resolved prediction of context-specific isoform variation with a graph-based attention model

2025-09-21

Abstract excerpt

In eukaryotes, most genes produce multiple transcript isoforms that diversify the transcriptome and proteome, serving as a key mechanism of functional regulation. Genetic variation can disrupt the RNA processing signals that shape isoform structure and abundance, yet modeling these effects at full-length isoform resolution remains challenging due to the complexity of transcript regulation. Here, we introduce Otari...

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Literature Corpus work: 23880e94-51d6-5357-b101-27fc2d089966
DOI: 10.1101/2025.09.18.677148

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