Article

RNA Editors Sculpt the Transcriptome During Terminal Erythropoiesis

2025-04-24

Abstract excerpt

<title>Abstract</title> <p>Selective RNA degradation during terminal erythropoiesis results in a globin-rich transcriptome in mature erythrocytes, but the specific RNA decay pathways remain unknown. We found that deficiency of the terminal uridylyl transferase enzyme Zcchc6 and the 3'-5' exoribonuclease Dis3l2 in mouse models led to fetal and perinatal reticulocytosis, an accumulation of RNA-rich precursors of te...

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Literature Corpus work: dc1e735b-ad7f-5d2f-b9e0-57eb94b0049d
DOI: 10.21203/rs.3.rs-6355281/v1

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