Article

RNA Editors Sculpt the Transcriptome During Terminal Erythropoiesis

2025-04-05

Abstract excerpt

<h4>ABSTRACT</h4> Selective RNA degradation during terminal erythropoiesis results in a globin-rich transcriptome in mature erythrocytes, but the specific RNA decay pathways remain unknown. We found that deficiency of the terminal uridylyl transferase enzyme Zcchc6 and the 3’-5’ exoribonuclease Dis3l2 in mouse models led to fetal and perinatal reticulocytosis, an accumulation of RNA-rich precursors of terminal er...

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Identifiers and source

Literature Corpus work: 04249d4c-957a-5fb9-aab4-fd5e2cf6c907
DOI: 10.1101/2025.04.03.647020

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