Article

A pooled CRISPR screen reveals genes critical for erythroblast enucleation

2026-04-07

Abstract excerpt

<h4>ABSTRACT</h4> Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained largely unknown, in part because the absence of genetic material in mature, en...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 32894e66-4b8c-5f3b-b15d-f75c8fd09af9
DOI: 10.64898/2026.04.06.716706

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A pooled CRISPR screen reveals genes critical for erythroblast enucleationDOI 10.64898/2026.04.06.716706Read

A genome-wide screen identifies genes required for erythroid differentiation.Semantic proximity Read

New insights into the mechanisms of red blood cell enucleation: From basics to clinical applicationsSemantic proximity Read

Molecular signature of erythroblast enucleation in human embryonic stem cellsSemantic proximity Read

A vesicle-based platform for high-efficiency, high-viability CRISPR/Cas9 knockout in primary human myeloid cellsSemantic proximity Read

Comprehensive Characterization and Global Transcriptome Analyses of Human Fetal Liver Terminal ErythropoiesisSemantic proximity Read

Defect in hematopoiesis and embryonic lethality at midgestation of <i>Vps13a/Vps13c</i> double knockout miceSemantic proximity Read

RNA Editors Sculpt the Transcriptome During Terminal ErythropoiesisSemantic proximity Read

Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide DonorsSemantic proximity Read

Human SEC23B-deficient hematopoietic stem cell model of CDAII recapitulates erythroid and cell-cycle defectsSemantic proximity Read

Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cellsSemantic proximity Read

RNA Editors Sculpt the Transcriptome During Terminal ErythropoiesisSemantic proximity Read

A new role of glutathione peroxidase 4 during human erythroblast enucleationSemantic proximity Read