Article

DCN1 inhibitor induces fetal hemoglobin through self-limited regulation of CUL3 neddylation

2026-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Few genetic loci are as well-characterized as the globin gene locus, and the substitution of healthy γ-globin (HbF) for missing or mutated β-globin (HbB) is an established therapeutic strategy for β-hemoglobinopathies including sickle cell disease (SCD) and β-thalassemia. Although substantial progress has been made in understanding HbF derepression and globin switching, many current therapeutic...

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Literature Corpus work: fb26bebe-0218-5ee9-9bf6-23ba25edc900
DOI: 10.64898/2026.04.22.720177

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