Hyperspiny Purkinje cell, a new neurological mutation in the mouse.

Abstract excerpt

Hyperspiny Purkinje cell (hpc) is a new autosomal recessive mutation of the laboratory mouse. Homozygotes exhibit abnormal motor behavior, with predominance of cerebellar symptoms, about 10 days after birth. Morphological analysis disclosed a slightly reduced cerebellum with selective alteration...

Topics

• Animals
• Cerebellum
• Genes, Recessive
• Mice
• Mice, Neurologic Mutants
• Mutation
• Purkinje Cells
• Synapses