Hyperspiny Purkinje cell, a new neurological mutation in the mouse.

Abstract excerpt

Hyperspiny Purkinje cell (hpc) is a new autosomal recessive mutation of the laboratory mouse. Homozygotes exhibit abnormal motor behavior, with predominance of cerebellar symptoms, about 10 days after birth. Morphological analysis disclosed a slightly reduced cerebellum with selective alteration of Purkinje cells. All these neurons have an atrophic dendritic tree. The proximal dendritic branches and the cell...

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