The toppler mouse: a novel mutant exhibiting loss of Purkinje cells.

doi:10.1002/cne.20206

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Article

The toppler mouse: a novel mutant exhibiting loss of Purkinje cells.

The Journal of comparative neurology - 16 Aug 2004

Duchala Cynthia S, Shick H Elizabeth, Garcia Jessica, Deweese Dannette M, Sun Xiaoyan, Stewart Valerie J, Macklin Wendy B

Abstract excerpt

We describe the genetic and neurological features of toppler, a spontaneous autosomal mutation that appeared in a colony of FVB/N mice and that manifests as severe ataxia appearing at around 12 days of age, worsening with age. The lifespan of affected mice is 8-12 months, with occasional mice living longer. Both homozygous males and females are fertile, and females are able to nurture litters. Histological...

Topics

Animals
Animals, Newborn
Ataxia
Cell Death
Central Nervous System
Cerebellum
Chromosome Mapping
Crosses, Genetic
Female
Fructose-Bisphosphate Aldolase
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Male

Mice

Mice, Neurologic Mutants

Mutation

Nerve Tissue Proteins

Neuroglia

Source

Open in PubMed

Identifiers

PMID: 15248193
DOI: 10.1002/cne.20206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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