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Article

The toppler mouse: a novel mutant exhibiting loss of Purkinje cells.

The Journal of comparative neurology - 16 Aug 2004

Duchala Cynthia S, Shick H Elizabeth, Garcia Jessica, Deweese Dannette M, Sun Xiaoyan, Stewart Valerie J, Macklin Wendy B

Abstract excerpt

We describe the genetic and neurological features of toppler, a spontaneous autosomal mutation that appeared in a colony of FVB/N mice and that manifests as severe ataxia appearing at around 12 days of age, worsening with age. The lifespan of affected mice is 8-12 months, with occasional mice living longer. Both homozygous males and females are fertile, and females are able to nurture litters. Histological...

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Identifiers

PMID: 15248193
DOI: 10.1002/cne.20206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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