Article

Biallelic inactivation ofTP53 rarely contributes to the development of malignant peripheral nerve sheath tumors

2001-02-01

Abstract excerpt

About 10% of the patients with neurofibromatosis type 1 (NF1) develop malignant peripheral nerve sheath tumors (MPNSTs), accounting for half of all MPNST cases. Several nonrandom chromosomal aberrations have been found, but the target genes remain mostly unrecognized. Mutations in the NF1 and TP53 genes have been found in some MPNSTs, and recent data from mouse models support a synergistic effect of these two gene...

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Literature Corpus work: dbf4b2da-ca7a-54fd-9f2f-60acb61d1bdf
DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1079>3.0.co;2-5

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