Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular heterogeneity in malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1.

Human genomics - 4 Sept 2012

Thomas Laura, Mautner Victor-Felix, Cooper David N, Upadhyaya Meena

Abstract excerpt

Neurofibromatosis type-1 (NF1), resulting from NF1 gene loss of function, is characterized by an increased risk of developing benign and malignant peripheral nerve sheath tumors (MPNSTs). Whereas the cellular heterogeneity of NF1-associated tumors has been well studied, the molecular heterogeneity of MPNSTs is still poorly understood. Mutational heterogeneity within these malignant tumors greatly complicates the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Neurofibromatosis 1
Share to Genes, p16
Share to Genes, p53

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Nerve Sheath Neoplasms

Share to Neurofibromatosis 1

Share to PTEN Phosphohydrolase

Share to Retinoblastoma Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 23244685
DOI: 10.1186/1479-7364-6-18
PMCID: PMC3500234

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular heterogeneity in malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1.PMID 23244685Read ↗

Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs).Semantic proximity Read ↗

Characterization of the somatic mutational spectrum of the neurofibromatosis type 1 (NF1) gene in neurofibromatosis patients with benign and malignant tumors.Semantic proximity Read ↗

Analysis of NF1 somatic mutations in cutaneous neurofibromas from patients with high tumor burden.Semantic proximity Read ↗

Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST.Semantic proximity Read ↗

Gene Expression Profiling Reveals Unique Molecular Subtypes of Neurofibromatosis Type I‐associated and Sporadic Malignant Peripheral Nerve Sheath TumorsSemantic proximity Read ↗

Exploring the somatic NF1 mutational spectrum associated with NF1 cutaneous neurofibromas.Semantic proximity Read ↗

Dissecting loss of heterozygosity (LOH) in neurofibromatosis type 1-associated neurofibromas: Importance of copy neutral LOHSemantic proximity Read ↗

The heterogeneous nature of germline mutations in NF1 patients with malignant peripheral serve sheath tumours (MPNSTs)Semantic proximity Read ↗

Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.Semantic proximity Read ↗

Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients.Semantic proximity Read ↗

Analysis of intratumor heterogeneity in Neurofibromatosis type 1 plexiform neurofibromas and neurofibromas with atypical features: Correlating histological and genomic findings.Semantic proximity Read ↗

Mechanisms of loss of heterozygosity in neurofibromatosis type 1-associated plexiform neurofibromas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.