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Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation.

Human genetics - 1 Aug 2021

Magallón-Lorenz Miriam, Fernández-Rodríguez Juana, Terribas Ernest, Creus-Batchiller Edgar, Romagosa Cleofe, Estival Anna, Perez Sidelnikova Diana, Salvador Héctor, Villanueva Alberto, Blanco Ignacio, Carrió Meritxell, Lázaro Conxi, Serra Eduard, Gel Bernat

Abstract excerpt

Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas with poor prognosis, developing either sporadically or in persons with neurofibromatosis type 1 (NF1). Loss of CDKN2A/B is an important early event in MPNST progression. However, many reported MPNSTs exhibit partial or no inactivation of CDKN2A/B, raising the question of whether there is more than one molecular path for MPNST...

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Share to Carcinogenesis
Share to Chromosomes, Human, Pair 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

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Share to Translocation, Genetic

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Identifiers

PMID: 34059954
DOI: 10.1007/s00439-021-02296-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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