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Article

A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1.

Mutation research - 3 Feb 2007

Garza Rene, Hudson Robert A, McMahan C Alex, Walter Christi A, Vogel Kristine S

Abstract excerpt

Defects in genes that control DNA repair, proliferation, and apoptosis can increase genomic instability, and thus promote malignant progression. Although most tumors that arise in humans with neurofibromatosis type 1 (NF1) are benign, these individuals are at increased risk for malignant peripheral nerve sheath tumors (MPNST). To characterize additional mutations required for the development of MPNST from benign...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17208258
DOI: 10.1016/j.mrfmmm.2006.11.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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