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Article

Biallelic inactivation of TP53 rarely contributes to the development of malignant peripheral nerve sheath tumors.

Genes, chromosomes & cancer - 1 Feb 2001

Lothe R A, Smith-Sørensen B, Hektoen M, Stenwig A E, Mandahl N, Saeter G, Mertens F

Abstract excerpt

About 10% of the patients with neurofibromatosis type 1 (NF1) develop malignant peripheral nerve sheath tumors (MPNSTs), accounting for half of all MPNST cases. Several nonrandom chromosomal aberrations have been found, but the target genes remain mostly unrecognized. Mutations in the NF1 and TP53 genes have been found in some MPNSTs, and recent data from mouse models support a synergistic effect of these two...

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PMID: 11135438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Biallelic inactivation of TP53 rarely contributes to the development of malignant peripheral nerve sheath tumors.PMID 11135438Read ↗

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