Article
Inferior survival for patients with malignant peripheral nerve sheath tumors defined by aberrant TP53.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2018
Høland Maren, Kolberg Matthias, Danielsen Stine Aske, Bjerkehagen Bodil, Eilertsen Ina A, Hektoen Merete, Mandahl Nils, van den Berg Eva, Smeland Sigbjørn, Mertens Fredrik, Sundby Hall Kirsten, Picci Piero, Sveen Anita, Lothe Ragnhild A
Abstract excerpt
Malignant peripheral nerve sheath tumor is a rare and aggressive disease with poor treatment response, mainly affecting adolescents and young adults. Few molecular biomarkers are used in the management of this cancer type, and although TP53 is one of few recurrently mutated genes in malignant peripheral nerve sheath tumor, the mutation prevalence and the corresponding clinical value of the TP53 network remains...
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