Article

Transient silencing of spinal nociceptive neurons leads to a long-term reduction in joint pain mediated by recruitment of opioid activity

2026-01-15

Abstract excerpt

Chronic inflammatory joint pain remains inadequately treated despite current therapies, creating urgent clinical need for non-addictive alternatives in an era of heightened opioid-related concerns. A promising new approach involves conjugates of botulinum toxin and substance P (SP-BOT), which, when infused locally or spinally, have been shown to produce temporary pain relief in neuropathic mouse models, with its e...

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Literature Corpus work: dbe5c5db-8974-5c9a-9268-16d44fdcbb2a
DOI: 10.64898/2026.01.14.699276

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