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Article

Microglial pannexin-1 channel activation is a spinal determinant of joint pain

3 Aug 2018

Abstract excerpt

panx suppressed the aberrant discharge of spinal laminae I-II neurons evoked by innocuous mechanical hindpaw stimulation in arthritic rats. Furthermore, mice with a microglia-specific genetic deletion of Panx1 were protected from developing mechanical allodynia. Treatment with probenecid, a clinically used broad-spectrum Panx1 blocker, resulted in a striking attenuation of MIA-induced mechanical allodynia and...

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PMID: 30101191
DOI: 10.1126/sciadv.aas9846

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