Article

Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targeting of WRN and ATR

2023-07-30

Abstract excerpt

Addiction to the WRN helicase is a unique vulnerability of human cancers with high levels of microsatellite instability (MSI-H). However, while prolonged loss of WRN ultimately leads to cell death, little is known about how MSI-H cancers initially respond to acute loss of WRN, knowledge that would be helpful for informing clinical development of WRN-targeting therapy, predicting possible resistance mechanisms, and...

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Literature Corpus work: dbe3734d-fbd3-5f2f-9459-d58e2dcce042
DOI: 10.1101/2023.07.28.550976

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