Article

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

2018-12-21

Abstract excerpt

Synthetic lethality, an interaction whereby the co-occurrence of two or more genetic events lead to cell death but one event alone does not, can be exploited to develop novel cancer therapeutics. DNA repair processes represent attractive synthetic lethal targets since many cancers exhibit an impaired DNA repair pathway, which can lead these cells to become dependent on specific repair proteins. The success of poly...

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Literature Corpus work: 8ecc18bc-5993-50ef-b718-e04a0afe658e
DOI: 10.1101/502070

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