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Clinical prospects of WRN inhibition as a treatment for MSI tumours

15 Nov 2022

Abstract excerpt

The discovery of synthetic lethal interactions with genetic deficiencies in cancers has highlighted several candidate targets for drug development, with variable clinical success. Recent work has unveiled a promising synthetic lethal interaction between inactivation/inhibition of the WRN DNA helicase and tumours with microsatellite instability, a phenotype that arises from DNA mismatch repair deficiency. While...

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PMID: 36379964
DOI: 10.1038/s41698-022-00319-y

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