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Article

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

24 Apr 2024

Abstract excerpt

Abstract The Werner syndrome RecQ helicase WRN was identified as a synthetic lethal target in cancer cells with microsatellite instability (MSI) by several genetic screens 1–6 . Despite advances in treatment with immune checkpoint inhibitors 7–10 , there is an unmet need in the treatment of MSI cancers 11–14 . Here we report the structural, biochemical, cellular and pharmacological characterization of the...

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PMID: 38658754
DOI: 10.1038/s41586-024-07350-y

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WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable CancersSemantic proximity Read ↗

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