Article

Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells

2019-01-26

Abstract excerpt

Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent large-scale genomic profiling and functional screening of cancer cell lines we identified Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite instability-high (MSI-H) cancer cells. MSI, caused by defective mismatch repair is frequently detected in human malignancies, in particul...

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Literature Corpus work: 9e612375-1a89-5720-a498-8f146ea175b9
DOI: 10.1101/530659

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