Article

Human induced pluripotent stem cell-derived microglia contribute to the pathophysiology of Fragile X syndrome via increased RAC1 signaling

2024-06-28

Abstract excerpt

Fragile X syndrome (FXS) is one of the most common monogenic causes of neurodevelopmental disorders characterized by intellectual disability, autism and epilepsy. Emerging evidence suggests a role for immune dysfunction in autism. Using induced pluripotent stem cell (iPSC)-derived microglial cells from FXS patients (mFXS-MG) and FMR1 -deficient microglia from FMR1 -knock out human embryonic stem cells ( FMR1 KO...

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Literature Corpus work: dbd82aee-cd1f-56cb-8103-f6b4f76e0ca2
DOI: 10.1101/2024.06.24.600387

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