Article

Computational modeling of optogenetic control in human atrial tissue: The role of fibrosis type and illumination strategy

2025-09-29

Abstract excerpt

Atrial fibrosis promotes atrial fibrillation by stabilizing spiral waves, with focal fibrosis causing strong anchoring that resists termination. Optogenetics offers a low-energy alternative for rhythm control, but its efficacy in human atrial tissue remains under investigation. Here, we developed a two-dimensional computational model of human atrial tissue expressing the light-sensitive protein GtACR1, coupled wit...

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Literature Corpus work: b405b84c-e41c-5978-8c0c-401e612dc241
DOI: 10.1101/2025.09.26.678713

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