Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the TGF-β/Smad3 pathway in pancreatic cancer cell growth and stem cell characteristics

6 Aug 2025

Abstract excerpt

Pancreatic cancer (PC) is a highly malignant digestive system tumor with poor prognosis, and cancer stem cell (CSC) is known to drive its progression, metastasis, and recurrence. The transforming growth factor-β (TGF-β)/small mothers against decapentaplegic 3 (Smad3) signaling is implicated in various cancers, yet its role in PC remains underexplored. This study aimed to investigate the involvement of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Mesenchymal stem cell research
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40768128
DOI: 10.1007/s12672-025-03220-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the TGF-β/Smad3 pathway in pancreatic cancer cell growth and stem cell characteristicsPMID 40768128Read ↗

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical SignificanceSemantic proximity Read ↗

SMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

Linc00462 promotes pancreatic cancer invasiveness through the miR-665/TGFBR1-TGFBR2/SMAD2/3 pathway.Semantic proximity Read ↗

Modulation of PRC1 Promotes Anticancer Effects in Pancreatic CancerSemantic proximity Read ↗

The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancerSemantic proximity Read ↗

TGF-β signaling in liver and gastrointestinal cancers.Semantic proximity Read ↗

Two sides of the story? Smad4 loss in pancreatic cancer versus head‐and‐neck cancerSemantic proximity Read ↗

The role of TGF-β/SMAD4 signaling in cancer.Semantic proximity Read ↗

MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer.Semantic proximity Read ↗

ZP3 Expression in Pancreatic Adenocarcinoma: Its Implications for the Prognosis and TherapySemantic proximity Read ↗

BAZ2A-SUV39H1-SMAD2/3-OCT4 regulates stemness, cell cycle exit and chemoresistance in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

TGF-βRII knock-down promotes tumor growth and chemoresistance to gemcitabine of pancreatic cancer cells via phosphorylation of STAT3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.