Article

Dysregulation of CELF4 splicing factor in pancreatic neuroendocrine tumors enhances aggressiveness and alters mTOR pathway and everolimus response

2022-11-21

Abstract excerpt

<title>Abstract</title> <p>Background Pancreatic neuroendocrine tumors (PanNETs) comprise a highly heterogeneous group of rare tumors, with growing incidence. Recent molecular analyses provided a precise picture of their genomic and epigenomic landscape. Splicing dysregulation is increasingly regarded as a novel cancer hallmark influencing all key tumor features. In this context, we have previously demonstrated...

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Literature Corpus work: cc05c9c8-aa71-5007-b3bf-b5a8b1040c2c
DOI: 10.21203/rs.3.rs-1879350/v1

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