Article

DL-CRISPR: A Deep Learning Method for Off-Target Activity Prediction in CRISPR/Cas9 With Data Augmentation

2020-01-01

Abstract excerpt

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR- associated (Cas) system is a popular and easy to use gene-editing technique, but it has off-target risk. Cutting the off-target sites will harm the cells severely, hence in silico methods are needed to help to avoid this. Most existing in silico approaches mainly relied on a relatively small positive dataset and the data imbalance issue sti...

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Literature Corpus work: faec0850-314a-580f-8693-85a74b9ca1e6
DOI: 10.1109/access.2020.2989454

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