Article

High-intensity interval training alleviates COPD-induced gastrocnemius muscle dysfunction via the BRD4/PGC-1α axis through restoring mitochondrial function and oxidative fiber composition

2025-09-30

Abstract excerpt

<title>Abstract</title> <p>Skeletal muscle dysfunction (SMD) associated with Chronic obstructive pulmonary disease (COPD), characterized by muscle atrophy and altered fiber type distribution. High-intensity interval training (HIIT) is increasingly used clinically to improve cardiopulmonary and exercise functions in COPD patients, yet robust scientific evidence and exploration of its molecular mechanisms remain li...

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Literature Corpus work: db8b5c0f-cce2-5e04-b7b2-f77382cb607d
DOI: 10.21203/rs.3.rs-7644902/v1

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