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Article

Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD.

Thorax - 1 Jan 2012

Lewis Amy, Riddoch-Contreras Joanna, Natanek Samantha A, Donaldson Anna, Man William D-C, Moxham John, Hopkinson Nicholas S, Polkey Michael I, Kemp Paul R

Abstract excerpt

RATIONALE: Muscle atrophy confers a poor prognosis in patients with chronic obstructive pulmonary disease (COPD), yet the molecular pathways responsible are poorly characterised. Muscle-specific microRNAs and serum response factor (SRF) are important regulators of muscle phenotype that contribute to a feedback system to regulate muscle gene expression. The role of these factors in the skeletal muscle dysfunction...

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Identifiers

PMID: 21998125
DOI: 10.1136/thoraxjnl-2011-200309
PMCID: PMC3240776

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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