Article
Fiber atrophy, oxidative stress, and oxidative fiber reduction are the attributes of different phenotypes in chronic obstructive pulmonary disease patients.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Dec 2013
Gouzi Fares, Abdellaoui Aldjia, Molinari Nicolas, Pinot Edith, Ayoub Bronia, Laoudj-Chenivesse Dalila, Cristol Jean-Paul, Mercier Jacques, Hayot Maurice, Préfaut Christian
Abstract excerpt
Peripheral muscle dysfunction, associated with reductions in fiber cross-sectional area (CSA) and in type I fibers, is a key outcome in chronic obstructive pulmonary disease (COPD). However, COPD peripheral muscle function and structure show great heterogeneity, overlapping those in sedentary healthy subjects (SHS). While discrepancies in the link between muscle structure and phenotype remain unexplained, we...
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