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Article

Electrical Stimulation Improves Rat Muscle Dysfunction Caused by Chronic Intermittent Hypoxia-Hypercapnia via Regulation of miRNA-Related Signaling Pathways.

PloS one - 1 Jan 2016

Pan Lu-Lu, Ke Jiang-Qiong, Zhao Cui-Cui, Huang Shi-Yuan, Shen Jie, Jiang Xian-Xun, Wang Xiao-Tong

Abstract excerpt

Skeletal muscle dysfunction in chronic obstructive pulmonary disease (COPD) patients is common. Neuromuscular Electrical Stimulation (NMES) is a powerful exercise training that may relieve muscle dysfunction in COPD. This study investigated whether electrical stimulation may have atypical adaptations via activation of miRNA related pathways in counteracting COPD muscle dysfunction. Forty-eight male Sprague-Dawley...

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Source

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Identifiers

PMID: 27023369
DOI: 10.1371/journal.pone.0152525
PMCID: PMC4811440

Genes

PGC
HDAC4
SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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