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Article

High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics

2025-11-13

Abstract excerpt

High-throughput physiologically based kinetic (HT-PBK) modelling provides a mechanistic framework for predicting systemic pharmacokinetics (PK) from in vitro and in silico data, supporting non-animal chemical safety assessment within Next generation risk assessment (NGRA). Here, we applied HT-PBK modelling to dermal exposure, a key route of human contact with chemicals. Using the skin permeation model of the Ope...

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Identifiers and source

Literature Corpus work
db784935-9193-52a0-8f49-b79b6cc2a93c
DOI
10.1101/2025.11.12.687995
Open publication

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High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokineticsDOI 10.1101/2025.11.12.687995
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