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Integrating a Microphysiological System and Physiologically Based Pharmacokinetic Modeling to Predict Human Responses to Diclofenac

2024-09-26

Abstract excerpt

<title>Abstract</title> <p>Conventional two-dimensional in vitro cell cultures and animal models often inadequately predict human pharmacokinetics (PKs) and pharmacodynamics owing to the complexity of human physiology and interspecies diversity. This study introduces an innovative approach integrating a microphysiological systems (MPS) with physiologically based pharmacokinetic (PBPK) modeling and transcriptomic...

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Literature Corpus work
93f1f08d-b54a-597c-9f09-4bc1e2caa983
DOI
10.21203/rs.3.rs-4954602/v1
Open publication

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Integrating a Microphysiological System and Physiologically Based Pharmacokinetic Modeling to Predict Human Responses to DiclofenacDOI 10.21203/rs.3.rs-4954602/v1
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