Article

A Human Next Generation PBK Model for PFOA

2026-02-07

Abstract excerpt

The human toxicological risk assessment of per- and polyfluoroalkyl substances (PFAS) is challenging, due to their sheer number and structural diversity, but also the paucity of the toxicity data required to characterize them. The development of Next Generation Physiologically Based Kinetic (NG-PBK) models may assist in overcoming this challenge. The mechanistic nature of NG-PBK models allows for their extrapolati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5759d3c-5610-5437-acf6-055cc5a1098b
DOI: 10.64898/2026.02.04.703497

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Human Next Generation PBK Model for PFOADOI 10.64898/2026.02.04.703497Read

High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokineticsSemantic proximity Read

The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAMs) in Pharmaceuticals and Environmental Chemical Risk AssessmentSemantic proximity Read

Systematic Evaluation of High-Throughput PBK Modelling Strategies for the Prediction of Intravenous and Oral Pharmacokinetics in HumansSemantic proximity Read

Enabling Transparent Toxicokinetic Modeling for Public Health Risk AssessmentSemantic proximity Read

Comparative sensitivity of <i>in vitro</i> acute and chronic apical and transcriptomic points of departure for perfluorooctanoic acid in human vascular endothelial cellsSemantic proximity Read

Evaluating Carcinogenic and Endocrine Disrupting Potential in Women’s Hygiene and Cosmetic FormulationsSemantic proximity Read

Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)Semantic proximity Read

High-throughput PBTK models for in vitro to in vivo extrapolationSemantic proximity Read

Use of physiologically based pharmacokinetic modeling to investigate individual versus population risk.Semantic proximity Read

Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment.Semantic proximity Read

Per- and polyfluoroalkyl substances concentrations are associated with an unfavorable cardio-metabolic risk profile: findings from two population-based cohort studiesSemantic proximity Read

High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterizationSemantic proximity Read